![]() ![]() They activate genes involved in the physiology of keratinocytes by binding to specific nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR). ![]() Skin conditions that may be treated with topical retinoids Trifarotene is approved for the treatment of lamellar ichthyosis by the FDA in the US.Congenital ichthyosis including recessive X-linked ichthyosis, epidermolytic ichthyosis, and erythrokeratoderma variabilis.Postinflammatory hyperpigmentation in dark skin.Kaposi sarcoma - FDA approved for localised HIV-related disease.Other topical retinoids used in dermatology Alitretinoin Topical retinoids may be used to treat many dermatoses - see the list of page links below (On DermNet). ![]() Topical isotretinoin, tretinoin, and adapelene have been used for localised Darier disease, reporting significant clinical improvement in symptoms. Topical tretinoin may be combined with other active ingredients in skin bleaching cream to treat melasma. If used longterm (>6 months) topical tretinoin can reduce freckling, solar lentigines, fine wrinkling, solar comedones, sun-induced skin fragility, and actinic keratoses . Topical retinoids can be used to treat facial acne They are particularly recommended for the treatment of acne in skin of colour. Topical retinoids are useful to treat post-inflammatory hyperpigmentation as they inhibit melanosome transfer and facilitate melanin dispersal. Inflammatory dermatoses including acne vulgaris may resolve with postinflammatory hyperpigmentation particularly in skin of colour. Topical retinoids may reduce the severity of existing scarring and subsequent acne scarring. It may take 12 weeks or longer before improvement is seen. They are effective first-line treatment for comedonal and inflammatory acne, but are not recommended as monotherapy for severe acne, especially if there are pustules with deep nodules and cysts. What are topical retinoids used for? Topical adapalene, isotretinoin, tretinoin, trifaroteneĪpplied to the face once daily at bedtime, topical retinoids such as adapalene, isotretinoin, tretinoin ( retinoic acid), and trifarotene can help mild to moderately severe acne. Topical retinoids are medications derived from vitamin A formulated as a cream, lotion, foam, emulsion, or gel. ![]()
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